Understanding how dietary sugars affect gut bacteria and health
Leveraging glycan-metabolite interactions to shape structure and function of the gut microbiome
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11133010
This study is looking at how certain foods can help good bacteria in your gut, especially a type called Bacteroides, to fight off diseases like colon cancer, and it aims to find ways to improve your gut health through better eating habits.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11133010 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between dietary glycans and gut bacteria, particularly focusing on the Bacteroides species, which are crucial for human health. By cataloging the microbiome and linking specific strains to their roles in diseases like colon cancer, the study aims to enhance beneficial bacteria and their functions. The approach involves using prebiotic dietary glycans to selectively target and promote healthy gut microbes while inhibiting harmful strains. This could lead to new dietary recommendations or therapies to improve gut health and prevent diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with gastrointestinal disorders, those at risk for colon cancer, or anyone interested in improving their gut health through dietary changes.
Not a fit: Patients with no gastrointestinal issues or those who do not consume a diet rich in glycans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary strategies or therapies that enhance gut health and reduce the risk of diseases such as colon cancer.
How similar studies have performed: Previous research has shown promising results in manipulating gut microbiomes through dietary interventions, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAKOFF-NAHOUM, SETH — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: RAKOFF-NAHOUM, SETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.