Understanding how dietary restriction affects health and longevity
Official title: Elucidating the roles of AMPylation and TGF-Beta signaling on eliciting the pro-health and longevity benefits of dietary restriction
Funded at University of Michigan at Ann Arbor · NIH-10997536 · Data updated 2026-11-12
This study is looking at how eating less can help us live healthier and longer by examining tiny worms to see how it affects important body signals and protein balance, which could lead to new ways to improve health as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,094 |
| NIH project number | 1F31AG085891-01A1 |
| Project ID | NIH-10997536 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the effects of dietary changes on health, particularly those at risk for age-related diseases such as type II diabetes and neurodegenerative disorders.
✕Less likely to help
Patients who are not interested in dietary interventions or who have conditions that prevent them from altering their diet may not benefit from this research.
What this research studies
This research investigates the mechanisms by which dietary restriction (DR) can enhance health and extend lifespan, focusing on the roles of specific signaling pathways in the body. By studying the model organism Caenorhabditis elegans, the research aims to uncover how DR influences the TGF-β signaling pathway and protein homeostasis, which are crucial for health benefits associated with aging. The study will explore the interaction between these pathways to identify potential interventions that could improve health outcomes for aging-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving health and longevity in aging populations.
How similar studies have gone: Previous research has shown promising results in understanding the health benefits of dietary restriction, particularly in model organisms, suggesting that this approach has potential for further breakthroughs.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Urban, Nicholas David — University of Michigan at Ann Arbor
- Study coordinator: Urban, Nicholas David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.