Understanding how dietary protein affects heart disease risk
Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and Atherosclerosis
This study looks at how eating a lot of protein, especially from animal sources, might affect heart health by contributing to the buildup of harmful plaques in your arteries, and it aims to find out how this happens so that better dietary advice can be given to help reduce the risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11067791 on NIH RePORTER |
What this research studies
This research investigates the impact of dietary protein on the development of atherosclerosis, a condition that leads to heart disease and strokes. It focuses on how high protein intake, particularly from animal sources, may contribute to the formation of harmful plaques in arteries. By studying the mechanisms involved, including specific signaling pathways in immune cells called macrophages, the research aims to uncover how protein consumption influences heart health. Patients may benefit from insights that could lead to dietary recommendations aimed at reducing cardiovascular disease risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are concerned about their cardiovascular health and dietary habits.
Not a fit: Patients who do not consume dietary protein or have no risk factors for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary guidelines that help reduce the risk of heart disease for patients.
How similar studies have performed: Previous studies have indicated that dietary factors significantly influence cardiovascular health, suggesting that this research could build on established findings.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Razani, Babak — University of Pittsburgh at Pittsburgh
- Study coordinator: Razani, Babak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.