Understanding how diet and genetics affect diabetes risk
Official title: Integration of dietary factors and multi-omic signatures of genetic subtypes to understand diabetes heterogeneity
Funded at Massachusetts General Hospital · NIH-11054140 · Data updated 2026-11-12
This study is looking at how what we eat and our genes work together to affect the risk of developing type 2 diabetes, with the goal of finding personalized diet tips to help prevent and manage the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $90,000 |
| NIH project number | 1K99DK139461-01A1 |
| Project ID | NIH-11054140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for type 2 diabetes, particularly those with a family history of the condition or specific genetic markers.
✕Less likely to help
Patients who do not have any risk factors for type 2 diabetes or those with other forms of diabetes unrelated to the genetic subtypes being studied may not benefit from this research.
What this research studies
This research investigates the complex relationship between dietary factors and genetic subtypes in adult-onset diabetes. By utilizing advanced omic technologies, the study aims to identify specific metabolic and gut microbiome signatures that contribute to the risk of developing type 2 diabetes. The research will analyze data from diverse cohorts to explore how these genetic differences can be influenced by diet, potentially leading to personalized dietary recommendations for diabetes prevention and management.
Why it matters
Potential benefit: If successful, this research could lead to tailored dietary interventions that significantly reduce the risk of type 2 diabetes for individuals based on their genetic makeup.
How similar studies have gone: Previous research has shown promising results in understanding diabetes through genetic and dietary interactions, indicating that this approach has the potential for significant insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Sevilla Gonzalez, Magdalena — Massachusetts General Hospital
- Study coordinator: Sevilla Gonzalez, Magdalena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.