Understanding how diet and genetics affect diabetes risk
Integration of dietary factors and multi-omic signatures of genetic subtypes to understand diabetes heterogeneity
['FUNDING_CAREER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11054140
This study is looking at how what we eat and our genes work together to affect the risk of developing type 2 diabetes, with the goal of finding personalized diet tips to help prevent and manage the condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11054140 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between dietary factors and genetic subtypes in adult-onset diabetes. By utilizing advanced omic technologies, the study aims to identify specific metabolic and gut microbiome signatures that contribute to the risk of developing type 2 diabetes. The research will analyze data from diverse cohorts to explore how these genetic differences can be influenced by diet, potentially leading to personalized dietary recommendations for diabetes prevention and management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for type 2 diabetes, particularly those with a family history of the condition or specific genetic markers.
Not a fit: Patients who do not have any risk factors for type 2 diabetes or those with other forms of diabetes unrelated to the genetic subtypes being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to tailored dietary interventions that significantly reduce the risk of type 2 diabetes for individuals based on their genetic makeup.
How similar studies have performed: Previous research has shown promising results in understanding diabetes through genetic and dietary interactions, indicating that this approach has the potential for significant insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEVILLA GONZALEZ, MAGDALENA — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SEVILLA GONZALEZ, MAGDALENA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus