Understanding how diet affects fat tissue changes
Deconstructing the diet-induced remodeling of adipose tissue
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-11046504
This study is looking at how being overweight affects fat tissue in your body, especially the fat around your organs, to help us understand how new fat cells form and grow, which can lead to health problems like diabetes, so you can learn more about what influences your weight and overall health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11046504 on ClinicalTrials.gov |
What this research studies
This research investigates how obesity, caused by excessive caloric intake, leads to changes in fat tissue, particularly in the visceral white adipose tissue. By using advanced techniques like single cell RNA sequencing, the study aims to identify the different cell types involved in fat tissue expansion and their roles in metabolic diseases such as diabetes. The research focuses on understanding how new fat cells are formed and how existing fat cells grow larger, which can contribute to inflammation and other health issues. Patients may learn more about the biological processes that affect their weight and metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are experiencing obesity or related metabolic disorders.
Not a fit: Patients who are underweight or do not have any metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity-related diseases like diabetes and cardiovascular conditions.
How similar studies have performed: Previous research has shown promising results in understanding the cellular mechanisms of obesity, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FARMER, STEPHEN ROBERT — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: FARMER, STEPHEN ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.