Understanding how diabetes affects nerve function in the stomach
Epigenetic dysregulation in diabetic enteric neuropathy
This study looks at how diabetes affects stomach nerves and can cause problems like nausea and bloating, and it aims to find new ways to help improve stomach function for people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10762970 on NIH RePORTER |
What this research studies
This research investigates the impact of diabetes on nerve function in the stomach, particularly focusing on conditions like delayed gastric emptying and gastroparesis. It explores how changes in gene expression and epigenetic regulation contribute to these issues, which can lead to symptoms such as nausea, bloating, and poor glucose control. By examining the role of specific proteins and cellular environments, the study aims to uncover potential therapeutic targets to improve nerve health and gastrointestinal function in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes experiencing gastrointestinal symptoms such as delayed gastric emptying or gastroparesis.
Not a fit: Patients without diabetes or those not experiencing gastrointestinal complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve stomach function and overall quality of life for patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of nerve function in diabetes, but this specific approach to epigenetic regulation is relatively novel.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Ordog, Tamas — Mayo Clinic Rochester
- Study coordinator: Ordog, Tamas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.