Understanding how diabetes affects lung function in cystic fibrosis patients
Official title: Mechanisms of mucociliary dysfunction in cystic fibrosis related diabetes
Funded at University of Kansas Medical Center · NIH-10812497 · Data updated 2026-11-12
This study is looking at how cystic fibrosis-related diabetes might affect lung health in adults with cystic fibrosis, and it hopes to find new ways to help improve lung function beyond just controlling blood sugar.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $660,756 |
| NIH project number | 5R01HL157942-04 |
| Project ID | NIH-10812497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with cystic fibrosis who also have cystic fibrosis-related diabetes.
✕Less likely to help
Patients without cystic fibrosis or those who do not have diabetes may not benefit from this research.
What this research studies
This research investigates the relationship between cystic fibrosis-related diabetes mellitus (CFRD) and lung function decline in adults with cystic fibrosis. It aims to explore the mechanisms behind mucociliary dysfunction and how hyperglycemia may contribute to worsening lung health. By analyzing data from patients on CFTR modulator therapies, the study seeks to identify new therapeutic approaches that go beyond just managing blood sugar levels. The research will involve both epidemiological and mechanistic studies to better understand the impact of CFRD on lung function.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance lung function and overall health for cystic fibrosis patients with diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the effects of diabetes on lung function in cystic fibrosis, but this specific approach is novel.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Salathe, Matthias a — University of Kansas Medical Center
- Study coordinator: Salathe, Matthias a
Related research
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Optimizing Treatments for People with Cystic Fibrosis on Highly Effective Modulator Therapy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.