Understanding how diabetes affects heart metabolism
Mechanism of metabolic remodeling in the diabetic heart
This study is looking at how the hearts of people with diabetes change their energy use and how certain tiny molecules might help heart cells work better, with the hope of finding ways to improve heart health for those living with diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10705337 on NIH RePORTER |
What this research studies
This research investigates the metabolic changes in the hearts of diabetic patients, focusing on how the heart cells adapt to decreased glucose use by increasing lipid uptake. It explores the role of specific enzymes and proteins in this process, particularly how the overexpression of a microRNA can improve heart cell function and energy efficiency. By using a novel mouse model, the study aims to identify mechanisms that could potentially reverse harmful metabolic changes in diabetic hearts, leading to better heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing heart-related issues.
Not a fit: Patients without diabetes or those with non-cardiac related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function in diabetic patients.
How similar studies have performed: Other research has shown promising results in understanding metabolic changes in diabetic hearts, but this specific approach is relatively novel.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Mishra, Paras Kumar — University of Nebraska Medical Center
- Study coordinator: Mishra, Paras Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.