Understanding how diabetes affects heart health using advanced cell models
Human iPSC Model to Elucidate Metabolic Interplay in Diabetic Cardimyopathy
This study is looking at how type 2 diabetes affects the heart, especially a condition called diabetic cardiomyopathy, and it aims to find out if certain medications can help protect heart cells in people with diabetes by using special lab techniques and mouse models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11077369 on NIH RePORTER |
What this research studies
This research investigates the relationship between type 2 diabetes and heart disease, specifically focusing on diabetic cardiomyopathy, a condition that affects heart muscle without the presence of high blood pressure. Researchers will use induced pluripotent stem cell (iPSC) technology to create models of heart cells from diabetic patients, allowing them to study how certain medications, like SGLT2 inhibitors, protect heart cells. The study will involve both laboratory experiments with engineered heart tissues and validation in diabetic mouse models to uncover the underlying mechanisms of heart protection. By understanding these processes, the research aims to identify new treatment strategies for patients with diabetes-related heart issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may be at risk for heart disease.
Not a fit: Patients without diabetes or those with heart conditions unrelated to diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better protect the heart in patients with diabetes.
How similar studies have performed: Previous research has shown promising results with SGLT2 inhibitors in improving heart health in diabetic patients, indicating that this approach has potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Wu, Joseph C. — Stanford University
- Study coordinator: Wu, Joseph C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.