Understanding how diabetes affects fat breakdown and heart disease
Project 3: Lipolysis regulation and diabetes-impaired regression
This study is looking at how high levels of fat in the blood can affect heart health in people with Type 2 diabetes, using special animal models to understand the role of certain genes and proteins, with the goal of finding better treatments for heart problems related to diabetes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10874525 on NIH RePORTER |
What this research studies
This research investigates the relationship between diabetes, particularly Type 2 diabetes, and cardiovascular disease (CVD) by focusing on how increased levels of triglycerides in the blood impact vascular health. The study will utilize new animal models to explore the role of specific genes and proteins involved in fat metabolism, particularly lipoprotein lipase (LPL), in the development of CVD. By examining how these factors interact within the arterial walls and affect immune cells, the research aims to uncover mechanisms that could lead to better treatments for patients with diabetes-related heart issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Type 2 diabetes who are at risk for cardiovascular disease.
Not a fit: Patients without diabetes or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cardiovascular disease in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the links between triglycerides and cardiovascular disease, making this approach both relevant and potentially impactful.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Goldberg, Ira J — University of Washington
- Study coordinator: Goldberg, Ira J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.