Understanding how diabetes affects bone marrow and immune function
Dissecting the Human Diabetic Bone Marrow Niche
['FUNDING_CAREER'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10884231
This study is looking at how type 2 diabetes affects the bone marrow and its ability to help heal wounds, especially for people with diabetic foot ulcers, by comparing samples from those with and without diabetes who have had amputations, to find better ways to treat these stubborn wounds.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10884231 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of type 2 diabetes on the bone marrow environment and its role in wound healing, particularly focusing on diabetic foot ulcers. By collecting and studying bone marrow samples from individuals with and without diabetes who have undergone amputation, the researchers aim to uncover how diabetes alters immune cell development and function. The study utilizes innovative techniques to culture and expand hematopoietic stem cells and mesenchymal progenitor cells, providing insights into the mechanisms that hinder healing in diabetic patients. The findings could lead to improved treatment strategies for diabetic foot ulcers, which are a significant health concern.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who have experienced or are at risk of developing diabetic foot ulcers.
Not a fit: Patients without diabetes or those who do not have diabetic foot ulcers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetic foot ulcers, potentially reducing the rate of amputations.
How similar studies have performed: Previous research has shown that understanding the bone marrow niche can lead to advancements in treating various conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NGUYEN, TAMMY TRAN — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: NGUYEN, TAMMY TRAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus