Understanding how diabetes affects blood platelet production
Official title: Thrombocytopoiesis in Diabetes: Role of Damage Associated Molecular Patterns
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10972793 · Data updated 2026-11-12
This study is looking at how high blood sugar in people with diabetes can lead to more blood clots by affecting certain blood cells, and it hopes to find ways to help improve blood health for those living with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | November 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $540,859 |
| NIH project number | 7R01HL137799-06 |
| Project ID | NIH-10972793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 or type 2 diabetes who are at risk for thrombotic events.
✕Less likely to help
Patients without diabetes or those with conditions unrelated to blood clotting may not benefit from this research.
What this research studies
This research investigates the mechanisms behind increased blood clotting risks in patients with diabetes, focusing on how high blood sugar levels influence the production of certain blood cells called reticulated platelets. The study examines the role of inflammatory signals from immune cells in the liver and fat, which may lead to increased platelet production. By exploring these pathways, the research aims to identify potential targets for improving blood health in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of blood clots in patients with diabetes.
How similar studies have gone: Previous research has shown that understanding inflammatory pathways can lead to significant advancements in managing diabetes-related complications, suggesting potential success for this approach.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Nagareddy, Prabhakara Reddy — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Nagareddy, Prabhakara Reddy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.