Understanding how developmental signals affect spinal disc health as we age
Role of Developmental Signaling Pathways in Maintenance of Spinal Discs
This study is looking at how certain signals in our bodies help keep our spinal discs healthy as we age, which could lead to new treatments for chronic back pain caused by disc problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-10833552 on NIH RePORTER |
What this research studies
This research investigates the role of specific developmental signaling pathways in the maintenance of spinal discs, particularly as they relate to aging. By using advanced techniques such as genetic mouse models and analysis of human disc samples, the researchers aim to identify key regulators that influence the growth and health of intervertebral discs. The study focuses on the sonic hedgehog (SHH) signaling pathway and its impact on disc cell function and health over time. Patients may benefit from insights gained that could lead to new therapies for chronic back pain associated with disc degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing chronic back pain or those at risk for intervertebral disc degeneration.
Not a fit: Patients who are younger than 21 years old or do not have issues related to spinal disc health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic back pain and improved spinal disc health in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of developmental signals in tissue maintenance, suggesting potential for success in this area.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Dahia, Chitra L — Hospital for Special Surgery
- Study coordinator: Dahia, Chitra L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.