Understanding how developmental problems and seizures interact in DEE
Dissecting the Developmental and Epileptic Components of Encephalopathy in DEE
This project looks at how genetic lesions and early-life seizures together cause developmental, behavioral, and sleep problems in people with developmental and epileptic encephalopathies (DEE).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11322073 on NIH RePORTER |
What this research studies
Researchers use mouse models based on human DEE genes and combine modern tools like EEG, calcium imaging, gene-expression (omics) analyses, and refined behavioral tests to separate the effects of the underlying lesion from the effects of seizures. They will improve preclinical measures for sleep, arousal, communication, feeding, and sensory integration so those measures better reflect the human condition. The team will compare timing of seizure exposure and developmental outcomes and identify molecular and circuit pathways that link seizures and neurodevelopmental decline. Findings are intended to point to targets and strategies that could be tested in future therapies for people with DEE.
Who could benefit from this research
Good fit: People with a diagnosis of developmental and epileptic encephalopathy, especially those with early-onset seizures or a known genetic cause, and families interested in research participation or future clinical trials are the most relevant candidates.
Not a fit: Patients with isolated adult-onset epilepsy without developmental delay or conditions unrelated to DEE are unlikely to directly benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to new treatments that improve learning, behavior, sleep, and communication in people with DEE beyond simply controlling seizures.
How similar studies have performed: Genetically informed animal studies have revealed mechanisms and targets for DEE, but translating those findings into therapies that improve developmental and behavioral outcomes has been limited so far.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Krishnan, Vaishnav — Baylor College of Medicine
- Study coordinator: Krishnan, Vaishnav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.