Understanding how Desmoglein-2 affects cell movement and gene expression.
Official title: The cadherin Desmoglein-2 controls cell spreading and extracellular matrix gene expression.
Funded at Furman University · NIH-10653447 · Data updated 2026-11-12
This study is looking at a protein called Desmoglein-2 to understand how it helps cells move and interact with their surroundings, which could provide helpful information for patients about how cell movement affects different diseases.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Furman University NIH-funded |
| Lab location | 1 site (Greenville, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $364,700 |
| NIH project number | 1R15GM150080-01 |
| Project ID | NIH-10653447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve altered cell migration or adhesion, such as certain cancers or skin disorders.
✕Less likely to help
Patients with stable conditions unrelated to cell movement or adhesion may not receive any benefit from this research.
What this research studies
This research investigates the role of Desmoglein-2, a protein involved in cell adhesion, in regulating how cells spread and interact with their environment. By examining the signaling pathways activated by Desmoglein-2, the study aims to uncover its influence on cell migration and gene expression related to the extracellular matrix. Patients may benefit from insights gained about how cell movement is controlled, which could have implications for various diseases where cell migration plays a critical role.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to abnormal cell movement, such as cancer metastasis or wound healing.
How similar studies have gone: While the specific role of Desmoglein-2 in cell migration is being explored, similar studies on cadherins have shown promising results in understanding cell behavior and adhesion.
Where this research is happening
-
Furman University
Greenville, United States Active
Researchers
- Principal investigator: Dubash, Adi D — Furman University
- Study coordinator: Dubash, Adi D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.