Understanding how depression affects thinking in older adults

Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults with Depression (ENSURE)

NIH-funded research Ut Southwestern Medical Center · NIH-10809673

This study is looking at how depression affects thinking in older adults, hoping to find ways to help improve their mental skills and overall well-being.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUt Southwestern Medical Center NIH-funded
Lab location1 site (Dallas, United States)
Project IDNIH-10809673 on NIH RePORTER

What this research studies

This research investigates the cognitive challenges faced by older adults with major depressive disorder (MDD), focusing on both emotional and non-emotional thinking processes. By examining how these cognitive functions are affected, the study aims to identify specific brain mechanisms that contribute to these challenges. Participants may undergo assessments that evaluate their cognitive abilities and emotional processing, which could lead to more personalized treatment approaches. The ultimate goal is to enhance the quality of life for older adults suffering from depression by improving their cognitive functioning.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 21 and above who are experiencing major depressive disorder.

Not a fit: Patients who are not experiencing depression or are under 21 years old may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better-targeted treatments that improve cognitive function and overall quality of life for older adults with depression.

How similar studies have performed: Previous research has shown promising results in understanding cognitive dysfunction in depression, suggesting that this approach could yield valuable insights.

Where this research is happening

Dallas, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.