Understanding how dengue virus antibodies develop and function
The evolution of dengue virus-reactive circulating antibody repertoire
This study is looking at how your immune system reacts to dengue virus infections, especially how your body’s antibodies and B cells change after getting the virus once or more, and it needs blood samples from patients to help find ways to create better treatments and vaccines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10770575 on NIH RePORTER |
What this research studies
This research investigates the immune response to dengue virus infections, focusing on how antibodies and B cells evolve after primary and secondary infections. By analyzing samples from a long-term cohort study in Nicaragua, the researchers aim to uncover the mechanisms that lead to broader protection against multiple dengue virus serotypes. The study will explore the role of memory B cells in generating effective antibodies that can neutralize the virus, which is crucial for developing better treatments and vaccines. Patients may be involved in providing blood samples to help understand these immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation include children aged 0-11 years who have experienced dengue virus infections.
Not a fit: Patients who have not been infected with any dengue virus serotype may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and vaccines for dengue fever, potentially reducing the incidence and severity of the disease.
How similar studies have performed: Previous research has shown promise in understanding antibody responses to viral infections, making this approach both relevant and potentially impactful.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Harris, Eva — University of California Berkeley
- Study coordinator: Harris, Eva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.