Understanding how dengue vaccination leads to long-lasting immunity
Long-term durability of DENV-specific immunity after vaccination in a dengue-endemic population
['FUNDING_U01'] · UNIVERSITY OF RHODE ISLAND · NIH-11051162
This study is looking at how well a dengue vaccine works in the long run by checking blood samples from people who have already taken the vaccine, to find out what helps keep their immunity strong over time.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF RHODE ISLAND (nih funded) |
| Locations | 1 site (KINGSTON, UNITED STATES) |
| Trial ID | NIH-11051162 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses generated by a dengue vaccine to determine what factors contribute to long-lasting immunity. By analyzing blood samples from participants in previous dengue vaccine trials, the study aims to identify specific immune cell responses and genetic profiles that correlate with durable protection against the virus. The research focuses on both T and B lymphocytes, which are crucial for the immune response, to uncover the mechanisms that lead to sustained antibody levels after vaccination.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received the dengue vaccine and are part of a dengue-endemic population.
Not a fit: Patients who have not been vaccinated against dengue or those living in non-endemic regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of dengue vaccines by identifying ways to promote long-lasting immunity in vaccinated individuals.
How similar studies have performed: Previous research has shown promising results in understanding vaccine-induced immunity, but this specific approach focusing on dengue vaccination is relatively novel.
Where this research is happening
KINGSTON, UNITED STATES
- UNIVERSITY OF RHODE ISLAND — KINGSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROTHMAN, ALAN L — UNIVERSITY OF RHODE ISLAND
- Study coordinator: ROTHMAN, ALAN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.