Understanding how dendrite structures grow and change in nerve cells
Dendrite structure: Data-Driven Models to Bridge from Molecules to Morphology
This study is looking at how tiny branches in nerve cells, called dendrites, grow and change in fruit flies, which can help us understand how these processes might be linked to brain conditions in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10991354 on NIH RePORTER |
What this research studies
This research focuses on the intricate structures of dendrites, which are essential for the communication and processing of information in the nervous system. By using advanced data-driven models, the study aims to predict how dendrites grow and change in specific neurons of the fruit fly, Drosophila. The researchers will explore the molecular interactions that influence dendritic growth, bridging the gap between genetic information and the physical structure of dendrites. This approach allows for a detailed understanding of how these structures develop and may relate to neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may be linked to dendritic structure abnormalities.
Not a fit: Patients with conditions unrelated to dendritic morphology or those not exhibiting neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of neurological diseases and potential therapeutic strategies.
How similar studies have performed: While the specific approach of using data-driven models for dendritic growth is innovative, similar research has shown promise in understanding neuronal structures and their implications in disease.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Howard, Jonathon — Yale University
- Study coordinator: Howard, Jonathon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.