Understanding how defective viral genomes affect RSV infections
Defective viral genomes in RSV pathogenesis
This study is looking at how certain types of viral genomes might affect how our bodies fight off respiratory syncytial virus (RSV) infections, helping us understand why some people get sicker than others, so we can find better ways to treat and prevent RSV, especially in kids and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11045014 on NIH RePORTER |
What this research studies
This research investigates the role of non-standard viral genomes, specifically copy-back genomes (cbVGs), in the pathogenesis of respiratory syncytial virus (RSV). By examining how these genomes influence antiviral immunity and disease outcomes in both children and adults, the study aims to identify key factors that determine the severity of RSV infections. The research employs a combination of in vitro experiments, animal models, and clinical data to unravel the complex interactions between the virus and the host's immune response. Ultimately, the goal is to develop better therapeutic strategies to reduce the public health burden of RSV.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old and adults over 21 who are at risk for severe RSV infections.
Not a fit: Patients with RSV infections who do not fall within the specified age ranges or who have unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for RSV infections, particularly in vulnerable populations such as young children and the elderly.
How similar studies have performed: Previous research has shown that understanding viral genome interactions can lead to significant advancements in managing viral infections, suggesting that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Lopez, Carolina B. — Washington University
- Study coordinator: Lopez, Carolina B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.