Understanding how defective HIV viruses cause ongoing inflammation
Defective HIV proviruses and Persistent Innate Immune Activation
['FUNDING_R01'] · BOSTON MEDICAL CENTER · NIH-11020156
This study is looking at how certain immune cells in people with HIV can cause ongoing inflammation that might lead to health problems, and it hopes to find new ways to help manage this issue better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11020156 on ClinicalTrials.gov |
What this research studies
This research investigates how HIV-infected CD4+ T cells and macrophages contribute to chronic inflammation, which can lead to various health issues in people living with HIV. The team will explore the role of defective HIV-1 proviruses that, despite being mutated, still produce viral RNA and may drive persistent immune activation. By examining the mechanisms behind this process, the research aims to uncover new insights into the relationship between HIV infection and inflammation, potentially leading to improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience chronic inflammation or related health issues.
Not a fit: Patients who are not infected with HIV or those who do not exhibit any inflammatory complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of inflammation-related complications in HIV patients.
How similar studies have performed: Previous research has shown that understanding the mechanisms of HIV persistence and immune activation can lead to significant advancements in treatment approaches.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HENDERSON, ANDREW J — BOSTON MEDICAL CENTER
- Study coordinator: HENDERSON, ANDREW J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus