Understanding how defective HIV viruses cause ongoing inflammation
Official title: Defective HIV proviruses and Persistent Innate Immune Activation
Funded at Boston Medical Center · NIH-11020156 · Data updated 2026-11-12
This study is looking at how certain immune cells in people with HIV can cause ongoing inflammation that might lead to health problems, and it hopes to find new ways to help manage this issue better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 22, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $765,274 |
| NIH project number | 1R01AI187175-01 |
| Project ID | NIH-11020156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who experience chronic inflammation or related health issues.
✕Less likely to help
Patients who are not infected with HIV or those who do not exhibit any inflammatory complications may not benefit from this research.
What this research studies
This research investigates how HIV-infected CD4+ T cells and macrophages contribute to chronic inflammation, which can lead to various health issues in people living with HIV. The team will explore the role of defective HIV-1 proviruses that, despite being mutated, still produce viral RNA and may drive persistent immune activation. By examining the mechanisms behind this process, the research aims to uncover new insights into the relationship between HIV infection and inflammation, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management of inflammation-related complications in HIV patients.
How similar studies have gone: Previous research has shown that understanding the mechanisms of HIV persistence and immune activation can lead to significant advancements in treatment approaches.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Henderson, Andrew J — Boston Medical Center
- Study coordinator: Henderson, Andrew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.