Understanding how deep brain stimulation helps with movement issues in Parkinson's disease
Mechanisms and effects of pallidal deep brain stimulation on levodopa resistant motor signs in Parkinson's disease
This study is looking at how deep brain stimulation can help people with Parkinson's disease who still have movement problems even after taking their usual medications, focusing on a part of the brain that might improve their movement and reduce issues like freezing while walking.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10930881 on NIH RePORTER |
What this research studies
This research investigates the effects of deep brain stimulation (DBS) on patients with Parkinson's disease who experience motor symptoms that do not respond to standard medication. The study focuses on a specific area of the brain called the globus pallidus and aims to understand how stimulation in this region can improve movement and reduce symptoms like freezing of gait. By using advanced techniques in DBS lead design, the research seeks to identify the pathways that mediate the benefits of this treatment. Patients may be monitored for changes in their motor function and overall quality of life as part of the research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Parkinson's disease who experience levodopa-resistant motor symptoms, particularly those related to gait and postural stability.
Not a fit: Patients who do not have Parkinson's disease or those whose motor symptoms are adequately managed with current therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with Parkinson's disease who suffer from difficult-to-treat motor symptoms.
How similar studies have performed: Previous research has shown promising results with deep brain stimulation in similar contexts, indicating that this approach may be effective for treating levodopa-resistant symptoms.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Mackinnon, Colum D — University of Minnesota
- Study coordinator: Mackinnon, Colum D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.