Understanding how decisions are made based on personal value assessments
Official title: Neuronal and theoretical analysis of subjective value representations
Funded at University of Oregon · NIH-11005325 · Data updated 2026-11-12
This study is looking at how people make choices when they struggle with addiction or brain issues, using tiny worms to understand the science behind these decisions, which could help create better treatments for those facing similar challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $400,637 |
| NIH project number | 5R35GM152169-02 |
| Project ID | NIH-11005325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing decision-making disorders, particularly those related to addiction or cognitive impairments.
✕Less likely to help
Patients who do not have decision-making disorders or cognitive deficits may not benefit from this research.
What this research studies
This research investigates how individuals make decisions based on their subjective evaluations of value, particularly in the context of addiction and cognitive deficits. By using the nematode worm C. elegans, which shares genetic similarities with humans, researchers aim to explore the biological underpinnings of decision-making processes. The study employs advanced microfluidic devices to observe how these worms choose between different food options, providing insights that could lead to better treatments for decision-making disorders. The findings may help in developing strategies to improve decision-making in individuals affected by brain injuries or addiction.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals struggling with addiction and cognitive deficits.
How similar studies have gone: Previous research has shown promise in using simpler organisms to understand complex decision-making processes, indicating potential for success in this approach.
Where this research is happening
-
University of Oregon
Eugene, United States Active
Researchers
- Principal investigator: Lockery, Shawn R — University of Oregon
- Study coordinator: Lockery, Shawn R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.