Understanding how DDX3 affects RNA processing and autism-related conditions
Investigating the role of DDX3 in regulating RNA structure and mRNA export
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10892645
This study is looking at how a protein called DDX3 affects the way our cells handle important messages (mRNA) and how changes in the DDX3 gene might be connected to autism and other developmental disorders, with the hope of finding new ways to help those who are affected.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10892645 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the DDX3 protein in regulating RNA structure and the export of messenger RNA (mRNA) from the nucleus to the cytoplasm. By studying how mutations in the DDX3 gene are linked to autism spectrum disorder and other neurodevelopmental diseases, the research aims to uncover the molecular mechanisms that disrupt normal cellular functions. The approach includes examining how DDX3 interacts with specific regions of mRNA and how these interactions are altered by pathogenic mutations. This could provide insights into potential therapeutic targets for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with mutations in the DDX3 gene, particularly those diagnosed with autism spectrum disorder or unexplained intellectual disabilities.
Not a fit: Patients without DDX3 mutations or those not diagnosed with autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autism spectrum disorder and related neurodevelopmental conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA metabolism in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, ALBERT Y — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: XU, ALBERT Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder