Understanding how DCAF7 affects blood stem cells
Official title: Elucidating the role of DCAF7 on hematopoietic stem cell maintenance
Funded at St. Jude Children's Research Hospital · NIH-10928213 · Data updated 2026-11-12
This study is looking at a protein called DCAF7 to see how it helps keep blood-making stem cells healthy, which is important for people with bone marrow issues or certain cancers, and it hopes to find new ways to improve treatments for these blood-related conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $134,549 |
| NIH project number | 5K01DK138265-02 |
| Project ID | NIH-10928213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those at risk of bone marrow failure, particularly those under 21 years of age.
✕Less likely to help
Patients with non-blood-related conditions or those over 21 years old may not receive direct benefits from this research.
What this research studies
This research investigates the role of a protein called DCAF7 in maintaining hematopoietic stem cells, which are crucial for producing blood cells. The study aims to uncover how changes in DCAF7 influence the function of these stem cells, particularly in relation to conditions like bone marrow failure and certain cancers. By examining the molecular mechanisms involved, the research seeks to identify potential new targets for drug development that could improve treatments for blood-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients with blood disorders by targeting the mechanisms that regulate blood stem cell function.
How similar studies have gone: Previous research has shown that targeting ubiquitin ligases can be effective in treating various blood disorders, suggesting that this approach may yield promising results.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Melo-Cardenas, Johanna — St. Jude Children's Research Hospital
- Study coordinator: Melo-Cardenas, Johanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.