Understanding how DCAF7 affects blood stem cells
Elucidating the role of DCAF7 on hematopoietic stem cell maintenance
['FUNDING_CAREER'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10928213
This study is looking at a protein called DCAF7 to see how it helps keep blood-making stem cells healthy, which is important for people with bone marrow issues or certain cancers, and it hopes to find new ways to improve treatments for these blood-related conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10928213 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called DCAF7 in maintaining hematopoietic stem cells, which are crucial for producing blood cells. The study aims to uncover how changes in DCAF7 influence the function of these stem cells, particularly in relation to conditions like bone marrow failure and certain cancers. By examining the molecular mechanisms involved, the research seeks to identify potential new targets for drug development that could improve treatments for blood-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or those at risk of bone marrow failure, particularly those under 21 years of age.
Not a fit: Patients with non-blood-related conditions or those over 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients with blood disorders by targeting the mechanisms that regulate blood stem cell function.
How similar studies have performed: Previous research has shown that targeting ubiquitin ligases can be effective in treating various blood disorders, suggesting that this approach may yield promising results.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELO-CARDENAS, JOHANNA — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: MELO-CARDENAS, JOHANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.