Understanding how dangerous bacteria resist antibiotics
Ribosome Quality Control Mechanisms in Gram-positive Bacteria
This research aims to discover how certain antibiotic-resistant bacteria, like those causing serious infections, manage their internal machinery to survive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11089606 on NIH RePORTER |
What this research studies
Many common and dangerous infections are caused by Gram-positive bacteria that have become resistant to antibiotics. We don't fully understand how these bacteria control their protein-making factories, called ribosomes, which is key to their survival and resistance. This project will explore how these bacteria fix problems with their ribosomes and how they use unusual ways to make proteins, which could reveal new weaknesses. By learning these secrets, we hope to find new ways to fight these tough infections.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly, but it focuses on understanding bacteria that cause infections in many people.
Not a fit: Patients not affected by Gram-positive bacterial infections or antibiotic resistance would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new antibiotics or treatment strategies for infections caused by antibiotic-resistant Gram-positive bacteria.
How similar studies have performed: While bacterial ribosomes have been studied for decades, this research explores newly discovered regulatory mechanisms and quality control processes in Gram-positive bacteria, suggesting a novel approach.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Feaga, Heather — Cornell University
- Study coordinator: Feaga, Heather
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.