Understanding how damaged mitochondria affect cell health and division
Global Intracellular Responses to Mitophagy
['FUNDING_OTHER'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-11090422
This study is looking at how a process called mitophagy, which helps get rid of damaged parts in our cells, affects different types of cells, especially stem cells, and how problems with this process might influence cell growth and the passing on of healthy cell parts, which could help us understand more about mitochondrial health and its connection to human diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-11090422 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitophagy, a process that removes damaged mitochondria, in various cell types, particularly stem cells. By using advanced techniques like live imaging and genetic screens, the study aims to uncover how defects in mitophagy can impact cell division and the inheritance of healthy mitochondria. The research will also explore the signaling pathways involved in these processes, which could provide insights into the broader implications of mitochondrial health in human diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases or conditions related to mitochondrial dysfunction.
Not a fit: Patients with conditions unrelated to mitochondrial health or those who do not have neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders.
How similar studies have performed: Previous research has shown that targeting mitochondrial health can lead to significant advancements in treating neurodegenerative diseases, suggesting a promising avenue for this study.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PICKRELL, ALICIA M — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: PICKRELL, ALICIA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers