Understanding how damaged cells can survive and signal cancer growth
Necrotic survivors and plasma membrane integrity signaling
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11014634
This study is looking at how damaged cells can still live and talk to each other, which might help tumors grow, and it aims to find ways to use this knowledge to improve cancer treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11014634 on ClinicalTrials.gov |
What this research studies
This research investigates how cells that have experienced damage to their plasma membranes can still survive and communicate with other cells. It focuses on a specific signaling pathway called Plasma Membrane Integrity signaling (PMI signaling), which may promote the secretion of substances that encourage tumor growth. By studying these 'necrotic survivors,' the researchers aim to uncover mechanisms that could be targeted to enhance cancer treatment. The approach includes identifying sensors that detect membrane damage and understanding the subsequent signaling processes involved.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with cancers that may be influenced by the signaling pathways of damaged cells.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cancer treatments by targeting the survival mechanisms of damaged cells.
How similar studies have performed: While the specific approach of targeting necrotic survivors is novel, related research has shown promise in understanding cell death and survival mechanisms in cancer.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GONG, YI-NAN — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: GONG, YI-NAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers