Understanding how daily biological rhythms affect brain activity
Circadian regulation of neocortex
This study is looking at how our daily routines affect brain cells in the motor cortex, especially how hormones influence their activity, and it’s designed to help us understand how our body clocks might shape brain function and behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10982509 on NIH RePORTER |
What this research studies
This research investigates how daily cycles influence the behavior of brain cells, particularly focusing on the motor cortex. By studying the effects of hormones like glucocorticoids on neurons and astrocytes, the researchers aim to uncover the mechanisms that regulate daily patterns of activity. Using advanced techniques such as machine learning and real-time imaging, they will analyze gene expression and calcium levels in specific cell types in mice. This approach could provide insights into how circadian rhythms impact brain function and behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline or symptoms related to Alzheimer's disease.
Not a fit: Patients with acute neurological injuries or those not affected by circadian rhythm disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing conditions like Alzheimer's disease by targeting circadian rhythms.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms and their effects on brain function, indicating potential for success in this area.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Herzog, Erik — Washington University
- Study coordinator: Herzog, Erik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.