Understanding how Cytomegalovirus affects HIV persistence
Mechanisms of CMV Replication on HIV Persistence
This study is looking at how Cytomegalovirus (CMV) might help keep HIV in the body for people living with HIV, even when they're on treatment, and it hopes to find new ways to help get rid of HIV for good.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10671025 on NIH RePORTER |
What this research studies
This research investigates the role of Cytomegalovirus (CMV) in sustaining HIV infection in individuals living with HIV. It aims to explore how CMV replication influences the immune system and contributes to the persistence of HIV, even in patients receiving antiretroviral therapy. The study will utilize advanced methods and existing biospecimens from clinical trials to analyze the interactions between various viral antigens and HIV-infected immune cells. By understanding these mechanisms, the research seeks to identify potential new strategies for HIV cure efforts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are also co-infected with Cytomegalovirus.
Not a fit: Patients who are not living with HIV or those without Cytomegalovirus co-infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for achieving an HIV cure by targeting the inflammatory processes driven by CMV.
How similar studies have performed: Previous research has shown that targeting viral co-infections can impact HIV persistence, suggesting that this approach may yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Gianella Weibel, Sara — University of California, San Diego
- Study coordinator: Gianella Weibel, Sara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.