Understanding how cysts form in a kidney disease
Modulation of cystogenesis
This study is looking into how certain proteins affect the growth of cysts in people with autosomal dominant polycystic kidney disease (ADPKD), with the hope of finding new ways to help manage the condition and improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11045094 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cyst formation in autosomal dominant polycystic kidney disease (ADPKD), a condition caused by mutations in the PKD1 gene. The team aims to explore how specific proteins, known as polycystins, influence various cellular processes and signaling pathways that contribute to the disease. By using advanced animal models and biochemical techniques, the researchers hope to identify factors that control cyst growth and progression, which could lead to new treatment strategies for patients. The ultimate goal is to enhance clinical care for individuals affected by ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of kidney cysts in patients with ADPKD.
How similar studies have performed: Previous research has shown promising results in understanding cystogenesis in ADPKD, but this approach aims to provide deeper insights and potentially novel treatment avenues.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zhou, Jing — Brigham and Women's Hospital
- Study coordinator: Zhou, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.