Understanding how cysts form and grow in a genetic kidney disease
Cyst induction and growth in ADPKD
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11167882
This study is looking at how a genetic condition called Autosomal Dominant Polycystic Kidney Disease (ADPKD) causes cysts to form in the kidneys, using special mouse models to learn more about the role of genetic changes, which could help find better treatments for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11167882 on ClinicalTrials.gov |
What this research studies
This research investigates Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic condition that leads to the formation of cysts in the kidneys. By using specially developed mouse models, the researchers aim to understand the mechanisms behind cyst formation and growth, particularly focusing on the role of genetic mutations. The study will explore how these mutations affect kidney cells and their environment, which could provide insights into the disease's progression. Patients may benefit from findings that could lead to new treatments or management strategies for ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease, particularly those with known mutations in the PKD1 or PKD2 genes.
Not a fit: Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with ADPKD.
How similar studies have performed: Previous research has shown promising results in understanding genetic mechanisms in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CEBRIAN LIGERO, CRISTINA — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: CEBRIAN LIGERO, CRISTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease