Understanding how cysts form and grow in a genetic kidney disease
Official title: Cyst induction and growth in ADPKD
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11167882 · Data updated 2026-11-12
This study is looking at how a genetic condition called Autosomal Dominant Polycystic Kidney Disease (ADPKD) causes cysts to form in the kidneys, using special mouse models to learn more about the role of genetic changes, which could help find better treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $490,868 |
| NIH project number | 5R01DK129238-02 |
| Project ID | NIH-11167882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease, particularly those with known mutations in the PKD1 or PKD2 genes.
✕Less likely to help
Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research investigates Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic condition that leads to the formation of cysts in the kidneys. By using specially developed mouse models, the researchers aim to understand the mechanisms behind cyst formation and growth, particularly focusing on the role of genetic mutations. The study will explore how these mutations affect kidney cells and their environment, which could provide insights into the disease's progression. Patients may benefit from findings that could lead to new treatments or management strategies for ADPKD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with ADPKD.
How similar studies have gone: Previous research has shown promising results in understanding genetic mechanisms in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Cebrian Ligero, Cristina — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Cebrian Ligero, Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.