Understanding how cystic fibrosis affects insulin release and diabetes.
Official title: Mechanisms of Islet Failure in CF
Funded at University of Alberta · NIH-10882447 · Data updated 2026-11-12
This study is looking at how certain cells in the pancreas work together and how problems with these cells can lead to diabetes in people with cystic fibrosis, so we can better understand and manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alberta NIH-funded |
| Lab location | 1 site (Edmonton, Canada) |
| Project start | September 19, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $437,156 |
| NIH project number | 1R01DK137209-01A1 |
| Project ID | NIH-10882447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and adults with cystic fibrosis who are experiencing diabetes or are at risk of developing it.
✕Less likely to help
Patients without cystic fibrosis or those who do not have diabetes related to cystic fibrosis may not benefit from this research.
What this research studies
This research investigates the mechanisms behind cystic fibrosis-related diabetes (CFRD), which significantly impacts individuals with cystic fibrosis. It focuses on how pancreatic ductal epithelial cells (PDECs) and islet cells interact and how their dysfunction contributes to impaired insulin release. By studying these cellular interactions and the effects of CFTR defects, the research aims to uncover the underlying causes of insulin deficiency in CFRD. Patients may be involved in studies that explore these cellular mechanisms and their implications for diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diabetes in cystic fibrosis patients.
How similar studies have gone: Previous research has indicated that understanding cellular mechanisms in similar contexts can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Alberta
Edmonton, Canada Active
Researchers
- Principal investigator: Hull-Meichle, Rebecca Lucy — University of Alberta
- Study coordinator: Hull-Meichle, Rebecca Lucy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.