Understanding how cyclin E affects metabolism in ovarian cancer
Official title: Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Funded at University of Pittsburgh at Pittsburgh · NIH-11123699 · Data updated 2026-11-12
This study is looking at how a protein called cyclin E affects the behavior of a specific type of ovarian cancer, with the goal of finding better treatment options that could work alongside current chemotherapy for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $198,750 |
| NIH project number | 3R01CA259111-04S1 |
| Project ID | NIH-11123699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with uterine serous carcinoma exhibiting high levels of cyclin E.
✕Less likely to help
Patients with other types of ovarian cancer or those without cyclin E amplification may not benefit from this research.
What this research studies
This research investigates the role of cyclin E in the metabolism of uterine serous carcinoma, a type of ovarian cancer. It aims to explore how high levels of cyclin E influence cancer cell behavior and their response to treatments. By examining the metabolic and epigenetic changes in these cancer cells, the study seeks to identify new therapeutic strategies that could enhance the effectiveness of existing chemotherapy. Patients may benefit from insights that could lead to more personalized and effective treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cyclin E high ovarian cancer.
How similar studies have gone: While the specific focus on cyclin E in this context is novel, similar approaches targeting metabolic pathways in cancer have shown promise in other studies.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Aird, Katherine Marie — University of Pittsburgh at Pittsburgh
- Study coordinator: Aird, Katherine Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.