Understanding how Cyclin D-Cdk4/6 promotes cell division in cancer
Project 1: Determine the mechanisms Cyclin D-Cdk4/6 uses to drive cell proliferation
This study is looking at how certain proteins help cancer cells grow and divide, especially in types of leukemia, and aims to find a way to stop this process, which could lead to new treatments for patients with these cancers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11046668 on NIH RePORTER |
What this research studies
This research investigates the role of Cyclin D-Cdk4/6 complexes in driving cell division, particularly in cancers like acute lymphoblastic leukemia. The project aims to identify the targets of these kinases and understand the molecular mechanisms involved in their activity. By using advanced biochemical and structural biology techniques, the researchers hope to develop a compound that can disrupt the interaction between Cyclin D and its target, potentially halting cancer cell proliferation. This work could lead to new therapeutic strategies for treating cancers with elevated Cdk4/6 activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute lymphoblastic leukemia or other cancers characterized by elevated Cdk4/6 activity.
Not a fit: Patients with cancers not associated with Cyclin D-Cdk4/6 activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively stop the growth of certain cancers, including acute lymphoblastic leukemia.
How similar studies have performed: Previous research has shown promising results in targeting Cyclin D-Cdk4/6 in various cancers, indicating that this approach has potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Skotheim, Jan M — Stanford University
- Study coordinator: Skotheim, Jan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.