Understanding how CYB5R1 affects cell death in blood vessel cells
Official title: Discerning the mechanisms of CYB5R1 regulation of ferroptosis in endothelial cells
Funded at University of Pittsburgh at Pittsburgh · NIH-10822260 · Data updated 2026-11-12
This study is looking at a protein called CYB5R1 that helps control cell death in the blood vessel lining, and by understanding how it works, we hope to find better ways to treat heart and blood vessel diseases that affect people like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL172522-01 |
| Project ID | NIH-10822260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cardiovascular diseases, particularly those with conditions that may involve endothelial dysfunction.
✕Less likely to help
Patients with non-cardiovascular related conditions or those not experiencing endothelial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of CYB5R1, a protein that helps regulate cell death in endothelial cells, which line blood vessels. By studying how this protein influences ferroptosis, a specific type of cell death linked to iron and oxidative stress, the researchers aim to uncover mechanisms that could lead to better understanding and treatment of cardiovascular diseases. The approach involves genetic analysis and biochemical assays to explore how changes in CYB5R1 levels affect cell survival and function. Patients may benefit from insights gained about endothelial cell health and its implications for cardiovascular conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases by targeting ferroptosis in endothelial cells.
How similar studies have gone: Other research has shown promising results in understanding cell death mechanisms in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Hall, Robert — University of Pittsburgh at Pittsburgh
- Study coordinator: Hall, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.