Understanding how CUX1 influences blood stem cell development
Official title: Establishing CUX1 as a determinant of hematopoietic stem cell fate
Funded at University of Chicago · NIH-11003972 · Data updated 2026-11-12
This study is looking at how a gene called CUX1 affects blood stem cells, which are important for making blood cells, to help us understand better how changes in this gene might relate to blood disorders like leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $427,408 |
| NIH project number | 5R01HL166184-03 |
| Project ID | NIH-11003972 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with blood disorders such as acute leukemia or myelodysplastic syndromes.
✕Less likely to help
Patients with non-hematological conditions or those without blood disorders may not benefit from this research.
What this research studies
This research investigates the role of the CUX1 gene in determining the fate of hematopoietic stem cells (HSCs), which are crucial for blood cell formation. By using a specially designed mouse model, researchers will measure CUX1 protein levels at a single-cell level during the development of these stem cells. The study aims to uncover how variations in CUX1 influence the behavior of blood stem cells, including their growth, self-renewal, and differentiation into various blood cell types. This could provide insights into conditions like acute leukemia and myelodysplastic syndromes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating blood disorders by targeting the mechanisms that control blood stem cell fate.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcription factors in stem cell behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Mcnerney, Megan — University of Chicago
- Study coordinator: Mcnerney, Megan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.