Understanding how curved bacteria like Vibrio cholerae form and function
Formation and function of cell curvature in Vibrio cholerae
This study is looking at how certain proteins help the bacteria that cause cholera, called Vibrio cholerae, to have their curved shape, which could help us better understand how these bacteria work and cause illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11073029 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the curvature of bacteria, specifically focusing on Vibrio cholerae. The team aims to explore how two proteins, CrvA and CrvB, contribute to the formation of curved shapes in these bacteria and their role in the bacterial cell wall. By studying these proteins and their interactions, the research seeks to fill gaps in knowledge regarding bacterial structure and function, which could have implications for understanding bacterial behavior and pathogenicity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by infections caused by Vibrio cholerae or similar bacterial pathogens.
Not a fit: Patients with non-bacterial infections or those not affected by Vibrio cholerae may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into bacterial behavior and potentially inform strategies for combating bacterial infections.
How similar studies have performed: While the study of bacterial curvature is an emerging field, previous research has shown promising results in understanding bacterial structures and their implications for pathogenicity.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Gitai, Zemer — Princeton University
- Study coordinator: Gitai, Zemer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.