Understanding how Cullin 3 affects heart function
Elucidating the role of Cullin 3 in the heart
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-11043400
This study is looking at how a protein called Cullin 3 helps keep the energy factories in heart cells working well, which is important for a healthy heart, and it hopes to find new ways to prevent heart problems like cardiomyopathy and heart failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11043400 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Cullin 3 in maintaining healthy mitochondria in heart cells, which is crucial for energy production and overall heart health. The study aims to identify how disruptions in mitochondrial function can lead to heart diseases like cardiomyopathy and heart failure. By exploring the mechanisms of mitochondrial biogenesis and turnover, the research seeks to uncover new regulatory pathways that could help prevent cardiac dysfunction. Patients may benefit from insights that could lead to novel therapeutic strategies for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are at risk for or suffering from heart-related conditions.
Not a fit: Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and reduce the risk of heart failure.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in heart health, indicating that this approach has potential for success.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SU, HUABO — AUGUSTA UNIVERSITY
- Study coordinator: SU, HUABO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
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