Understanding how Cullin 3 affects heart function
Official title: Elucidating the role of Cullin 3 in the heart
Funded at Augusta University · NIH-11043400 · Data updated 2026-11-12
This study is looking at how a protein called Cullin 3 helps keep the energy factories in heart cells working well, which is important for a healthy heart, and it hopes to find new ways to prevent heart problems like cardiomyopathy and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $600,673 |
| NIH project number | 5R01HL173796-02 |
| Project ID | NIH-11043400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or suffering from heart-related conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of Cullin 3 in maintaining healthy mitochondria in heart cells, which is crucial for energy production and overall heart health. The study aims to identify how disruptions in mitochondrial function can lead to heart diseases like cardiomyopathy and heart failure. By exploring the mechanisms of mitochondrial biogenesis and turnover, the research seeks to uncover new regulatory pathways that could help prevent cardiac dysfunction. Patients may benefit from insights that could lead to novel therapeutic strategies for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and reduce the risk of heart failure.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function in heart health, indicating that this approach has potential for success.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Su, Huabo — Augusta University
- Study coordinator: Su, Huabo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.