Understanding how CSPalpha affects brain cell health and function
Investigating the role of CSPalpha in presynaptic autophagy
['FUNDING_R21'] · YALE UNIVERSITY · NIH-11116139
This study is looking at a protein called CSPα to see how it helps keep brain cells healthy by cleaning up damaged proteins, which could help us understand more about diseases like Alzheimer's and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11116139 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Cysteine String Protein α (CSPα) in maintaining the health of brain cells, particularly focusing on its involvement in the process of autophagy, which is crucial for clearing damaged proteins. By studying both normal and mutated forms of CSPα in brain models, the research aims to uncover how disruptions in this protein contribute to neurodegenerative diseases like Alzheimer's. The team will utilize advanced techniques such as electron microscopy and live imaging to observe changes in synaptic structures and protein turnover. This work could provide insights into the mechanisms of neurodegeneration and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients with neurodegenerative conditions unrelated to protein folding or synaptic health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases like Alzheimer's.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein chaperones in neurodegeneration, indicating that this approach has potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANDRA, SREEGANGA S — YALE UNIVERSITY
- Study coordinator: CHANDRA, SREEGANGA S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome