Understanding how Cryptosporidium interacts with its host cells
Official title: Interrogating the molecular architecture of the Cryptosporidium host-parasite interface
Funded at University of Pennsylvania · NIH-10900977 · Data updated 2026-11-12
This study is looking at how the Cryptosporidium parasite interacts with the cells in our body, using special imaging tools to see how it hides from our immune system and gets the nutrients it needs, which could help us find better ways to treat infections caused by this parasite.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32AI183654-01 |
| Project ID | NIH-10900977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals, particularly children and adults, who are affected by or at risk of Cryptosporidium infections.
✕Less likely to help
Patients who are not affected by Cryptosporidium infections or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the complex interactions between the Cryptosporidium parasite and its host cells, focusing on the unique structures that allow the parasite to survive and thrive within the host. By using advanced imaging techniques, the study aims to visualize the three-dimensional architecture of the host-parasite interface, which is crucial for understanding how the parasite evades the immune system and extracts nutrients. The research will involve detailed analysis of the molecular components involved in these interactions, potentially leading to new insights into treatment options for infections caused by Cryptosporidium.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments or vaccines for Cryptosporidium infections, significantly reducing diarrheal disease in children and adults.
How similar studies have gone: Other research on similar intracellular parasites has shown promising results in understanding host-parasite interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Cohen, Allison — University of Pennsylvania
- Study coordinator: Cohen, Allison
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.