Understanding how Cryptosporidium infects hosts
Official title: Genetic Basis of Host Infectivity by Cryptosporidium
Funded at Washington University · NIH-10983765 · Data updated 2026-11-12
This study is looking at how the genes of the Cryptosporidium parasite affect how it makes people sick, especially in those with weakened immune systems and babies, to help us find better ways to treat and prevent these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | November 9, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $656,207 |
| NIH project number | 5R01AI175150-02 |
| Project ID | NIH-10983765 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include immunocompromised individuals and infants who are at higher risk for severe infections from Cryptosporidium.
✕Less likely to help
Patients who are healthy and have a robust immune system may not benefit directly from this research.
What this research studies
This research investigates the genetic factors that influence how the Cryptosporidium parasite infects different hosts, particularly focusing on its impact on immunocompromised individuals and infants. By studying various strains of C. parvum, the research aims to identify genetic variations that affect the severity of infections and the ability of the parasite to spread. The team utilizes advanced techniques, including whole genome sequencing and a novel stem-cell derived system for culturing intestinal cells, to explore these dynamics in a controlled environment. The findings could lead to better understanding and management of Cryptosporidium infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for severe diarrheal diseases caused by Cryptosporidium, particularly in vulnerable populations.
How similar studies have gone: Other research has shown promising results in understanding host-pathogen interactions, making this approach both relevant and potentially impactful.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Sibley, L. David — Washington University
- Study coordinator: Sibley, L. David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.