Understanding how cryptic splicing affects gene regulation and cellular behavior
Regulation and consequences of cryptic splicing
This study is looking at how RNA is put together in our cells and what happens when it goes wrong, which could help us understand diseases like cancer and neurodegeneration, so that patients can benefit from better treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11061063 on NIH RePORTER |
What this research studies
This research investigates the complex process of RNA splicing, which is essential for gene regulation and the diversity of RNA transcripts. It focuses on cryptic splicing, a phenomenon where incorrect splicing occurs, potentially leading to diseases such as cancer and neurodegeneration. By studying the interactions of RNA binding proteins with introns, the research aims to uncover the mechanisms that control splicing and how disruptions can affect cellular functions. Patients may benefit from insights gained into how these processes contribute to various pathologies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with genetic disorders or cancers associated with splicing abnormalities.
Not a fit: Patients with conditions unrelated to RNA splicing or those not affected by genetic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to splicing errors, such as certain cancers and neurodegenerative disorders.
How similar studies have performed: Previous research has shown that understanding RNA splicing mechanisms can lead to significant advancements in treating related diseases, indicating a promising avenue for this investigation.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Cheng, Chonghui — Baylor College of Medicine
- Study coordinator: Cheng, Chonghui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.