Understanding how crossovers form during the creation of reproductive cells
Official title: Formation and Regulation of Meiotic Crossovers
Funded at Stanford University · NIH-11222443 · Data updated 2026-11-12
This study is looking at how cells make reproductive cells, like sperm and eggs, by understanding how certain DNA breaks turn into important crossovers that help chromosomes divide correctly, which is important for anyone interested in how our bodies create new life.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $3,000 |
| NIH project number | 3F32GM153100-01A1S1 |
| Project ID | NIH-11222443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals or families with a history of miscarriages or birth defects potentially linked to chromosomal abnormalities.
✕Less likely to help
Patients who do not have a history of reproductive issues or chromosomal abnormalities may not receive direct benefits from this research.
What this research studies
This research investigates the process of meiosis, which is essential for the formation of reproductive cells in diploid organisms like humans. It focuses on the formation of crossovers, which are critical for proper chromosome segregation during cell division. The study aims to understand how certain DNA breaks are selected to become crossovers and the mechanisms that ensure their formation while limiting others. By exploring these processes, the research seeks to uncover the balance between the risks of DNA damage and the need for accurate chromosome pairing.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of aneuploidy, which is a major cause of miscarriages and birth defects.
How similar studies have gone: Previous research has shown success in understanding meiotic processes, but this specific investigation into crossover formation is exploring novel aspects of the mechanism.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Uebel, Celja — Stanford University
- Study coordinator: Uebel, Celja
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.