Understanding how creeping fat contributes to strictures in Crohn's disease
Creeping fat and Crohn's disease associated strictures
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10817920
This study is looking at how fat in the abdomen affects the intestines in people with Crohn's disease, hoping to find new ways to help prevent or treat blockages in the intestines.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10817920 on ClinicalTrials.gov |
What this research studies
This research investigates the role of creeping fat in the development of intestinal strictures in patients with Crohn's disease. It aims to understand the mechanisms behind how mesenteric fat interacts with intestinal muscle cells, leading to thickening of the intestinal wall and obstruction. By studying the metabolic processes involved, the research seeks to identify potential new therapeutic targets to prevent or treat these strictures. Patients may benefit from insights that could lead to improved management strategies for Crohn's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease who experience or are at risk of developing intestinal strictures.
Not a fit: Patients with Crohn's disease who do not have strictures or creeping fat may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent intestinal obstructions in Crohn's disease patients.
How similar studies have performed: While the specific mechanisms of creeping fat in Crohn's disease are not extensively studied, similar research approaches have shown promise in understanding other aspects of inflammatory bowel diseases.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIEDER, FLORIAN — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: RIEDER, FLORIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.