Understanding how CREB affects communication between brain cells in Alzheimer's disease
Regulation and functions of CREB in excitatory synapses of hippocampal neurons
['FUNDING_R21'] · GEORGETOWN UNIVERSITY · NIH-11042200
This study is looking at how a protein called CREB helps brain cells talk to each other in the hippocampus, especially in people with Alzheimer's, to find new ways to help improve memory and learning.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11042200 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called CREB in the communication between neurons in the hippocampus, particularly in the context of Alzheimer's disease. By examining how CREB influences synaptic plasticity, which is the ability of synapses to strengthen or weaken over time, the research aims to uncover new mechanisms that could be targeted for therapeutic interventions. The study will utilize advanced techniques to observe changes in neuron behavior and gene expression in response to different stimuli. Patients may benefit from insights gained about how synaptic dysfunction contributes to Alzheimer's disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing early signs of cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing cognitive decline in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAK, DANIEL T — GEORGETOWN UNIVERSITY
- Study coordinator: PAK, DANIEL T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease