Understanding how CREB affects communication between brain cells in Alzheimer's disease
Official title: Regulation and functions of CREB in excitatory synapses of hippocampal neurons
Funded at Georgetown University · NIH-11042200 · Data updated 2026-11-12
This study is looking at how a protein called CREB helps brain cells talk to each other in the hippocampus, especially in people with Alzheimer's, to find new ways to help improve memory and learning.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $191,920 |
| NIH project number | 5R21NS136976-02 |
| Project ID | NIH-11042200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing early signs of cognitive impairment.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not receive benefit from this research.
What this research studies
This research investigates the role of a protein called CREB in the communication between neurons in the hippocampus, particularly in the context of Alzheimer's disease. By examining how CREB influences synaptic plasticity, which is the ability of synapses to strengthen or weaken over time, the research aims to uncover new mechanisms that could be targeted for therapeutic interventions. The study will utilize advanced techniques to observe changes in neuron behavior and gene expression in response to different stimuli. Patients may benefit from insights gained about how synaptic dysfunction contributes to Alzheimer's disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing cognitive decline in Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding synaptic mechanisms in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Pak, Daniel T — Georgetown University
- Study coordinator: Pak, Daniel T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.