Understanding how craniofacial skeletal cells can regenerate stem cells and their environments
Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their niches
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11043350
This study is looking at how certain cells in the face and skull can change and help heal injuries or deformities, with the goal of finding new treatments to improve healing in these areas.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11043350 on ClinicalTrials.gov |
What this research studies
This research investigates the ability of craniofacial skeletal cells to adapt and regenerate stem cells and their supporting environments, which are crucial for healing craniofacial deformities and bone loss. By examining the molecular and cellular mechanisms that allow these cells to change and fulfill different roles, the research aims to develop innovative therapies that can restore the natural regenerative capacity of craniofacial tissues. The approach includes advanced techniques like lineage tracing and transcriptomic analysis to gain insights into how these cells function and interact in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with craniofacial deformities or significant alveolar bone loss due to periodontal diseases.
Not a fit: Patients with non-craniofacial skeletal issues or those who do not have significant skeletal deformities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively restore craniofacial structures and improve healing in patients with severe skeletal conditions.
How similar studies have performed: While the specific approach of this research is innovative, similar studies have shown promise in understanding cell plasticity and regeneration in other contexts.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ONO, NORIAKI — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: ONO, NORIAKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.