Understanding how cranial mesenchyme growth affects brain development
Regulation of Cranial Mesenchyme Expansion Driving Neural Fold Elevation
['FUNDING_R01'] · CHILDREN'S RESEARCH INSTITUTE · NIH-10794250
This study is looking at how certain genetic changes can lead to serious birth defects in the brain and spine, using a special mouse model to understand how specific cells help the neural tube close properly during development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10794250 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind neural tube defects (NTDs), which are serious birth defects affecting brain and spinal cord development. By studying a novel mouse model with a specific genetic mutation, the researchers aim to uncover how the growth of cranial mesenchyme cells influences the elevation of neural folds necessary for proper neural tube closure. The study employs advanced methodologies to analyze cellular movements and genetic factors that may contribute to NTDs, providing insights into both normal and abnormal developmental processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents with a family history of neural tube defects or those who have had previous pregnancies affected by such conditions.
Not a fit: Patients with neural tube defects that are not linked to genetic factors or those with unrelated congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential prevention strategies for neural tube defects in humans.
How similar studies have performed: Previous research has shown promise in understanding genetic contributions to neural tube defects, making this approach both relevant and potentially impactful.
Where this research is happening
WASHINGTON, UNITED STATES
- CHILDREN'S RESEARCH INSTITUTE — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZOHN, IRENE E — CHILDREN'S RESEARCH INSTITUTE
- Study coordinator: ZOHN, IRENE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.