Understanding how Coxiella burnetii survives inside cells
Coxiella survival mechanisms in the intracellular niche
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10923506
This study is looking at how the bacteria that cause Q fever survive in tough conditions inside our cells, with the goal of finding new ways to help treat people who have chronic Q fever and need better treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10923506 on ClinicalTrials.gov |
What this research studies
This research investigates the survival mechanisms of Coxiella burnetii, the bacteria responsible for Q fever, which can lead to severe health issues. The study focuses on how this pathogen thrives in acidic environments within host cells and aims to identify factors that help it maintain a suitable internal pH. By exploring the bacteria's metabolic processes and its interaction with host cell components, the research seeks to uncover potential new therapeutic targets for treating Q fever. Patients with chronic Q fever often require long-term antibiotic treatment, making this research particularly relevant for improving treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute or chronic Q fever, particularly those experiencing severe symptoms or complications.
Not a fit: Patients who do not have Q fever or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Q fever, potentially reducing the duration and severity of antibiotic therapy for patients.
How similar studies have performed: Previous research has shown promise in understanding bacterial survival mechanisms, but this specific approach to studying Coxiella burnetii is relatively novel.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILK, STACEY D — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: GILK, STACEY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.