Understanding how Coxiella burnetii survives inside cells
Coxiella survival mechanisms in the intracellular niche
This study is looking at how the bacteria that cause Q fever survive and stay healthy inside our cells, with the goal of finding new ways to treat the illness, especially for those who have it for a long time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10862736 on NIH RePORTER |
What this research studies
This research investigates the survival mechanisms of Coxiella burnetii, the bacteria responsible for Q fever, which can lead to severe health issues. The study focuses on how this pathogen thrives in the acidic environment of infected cells and aims to identify factors that help it maintain a stable internal pH. By exploring the bacteria's metabolic processes and its interaction with host cells, the research seeks to uncover new therapeutic targets for treating Q fever, especially in chronic cases that require long-term antibiotic treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute or chronic Q fever, particularly those experiencing severe symptoms or complications.
Not a fit: Patients with other unrelated infections or conditions that do not involve Coxiella burnetii may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Q fever, reducing the duration and severity of illness for patients.
How similar studies have performed: Previous research has shown promise in understanding bacterial survival mechanisms, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Gilk, Stacey D — University of Nebraska Medical Center
- Study coordinator: Gilk, Stacey D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.